CROHN'S DISEASE

Stop Guessing Which
Biologic Will Work

CrohnProfile™ identifies your dominant immune pathways—IL-23, TNF-α, or mixed—so you start with the right medication from day one.

See Testing Options How It Works

The Trial-and-Error Problem

Your doctor picks a biologic and hopes it works. If not, you try another one 6 months later. Then another. Meanwhile, your disease progresses and permanent damage occurs.

The Average Crohn's Patient:

  • Tries 3-5 different biologics
  • Wastes 18-36 months finding one that works
  • Spends $60,000-$150,000 on failed treatments
  • Experiences permanent intestinal damage during this time

The PathwayBio Solution

Test your immune pathways before starting biologics. Know if you're IL-23 dominant (try Skyrizi), TNF-α driven (try Humira), or have mixed pathways (try Stelara). Start with the medication most likely to work for your immune system.

Choose Your Testing Package

Select the level of analysis that's right for your situation

MOST POPULAR

CrohnProfile™

Core Panel

$395

One-time payment

What's Included:

  • ✓ 32+ biomarkers analyzed
  • ✓ IL-23, IL-17, TNF-α, IL-12, IL-6, IL-10 pathways
  • ✓ ASCA IgA/IgG, pANCA antibodies
  • ✓ Fecal calprotectin (inflammation)
  • ✓ Complete blood work (CBC, CMP, liver)
  • ✓ AI-powered pathway identification
  • ✓ Biologic matching (Skyrizi, Stelara, Humira, etc.)
  • ✓ Clinical trial matching

Best For:

Newly diagnosed patients, those starting their first biologic, or patients considering treatment escalation.

Full Details →
COMPREHENSIVE

CrohnProfile Plus™

Enhanced Panel

$595

One-time payment

Everything in Core PLUS:

  • ✓ 53 total biomarkers (21 additional)
  • ✓ Anti-drug antibodies (why biologics fail)
  • ✓ IL-1β, IL-8, IL-22, TGF-β pathways
  • ✓ Oxidative stress markers
  • ✓ Complement C3, C4 (immune activation)
  • ✓ Fibrosis risk assessment (TGF-β)
  • ✓ Celiac screening
  • ✓ C. difficile infection screening

Best For:

Patients who failed multiple biologics, investigating why treatments aren't working, or preparing for surgery.

Full Details →

Not sure which package is right for you?

Create a free account and get personalized recommendations →

How CrohnProfile Works

1

Order Your Panel

Choose CrohnProfile or CrohnProfile Plus. We ship a collection kit to your home with everything you need.

2

Collect Sample

Visit a local lab for blood draw (or add at-home phlebotomy for $50). Collect stool sample for calprotectin.

3

Ship to Lab

Use prepaid shipping label to send samples to our CLIA-certified partner laboratory.

4

Lab Processing

Comprehensive analysis of 32-53 biomarkers takes 10-14 business days.

5

AI Interpretation

Our AI identifies your dominant pathways and generates your personalized immune profile report.

6

Get Matched

Receive biologic matches ranked by compatibility score, plus clinical trial options and advocacy resources.

Real Matching Example

How CrohnProfile guides treatment selection

Patient Profile:

Sarah, 32 years old
Diagnosed with moderate Crohn's disease 6 months ago. Mesalamine and prednisone provided minimal relief. Doctor recommends starting a biologic but isn't sure which one.

CrohnProfile Results:

Dominant Pathway: IL-23/IL-17 (Th17)
IL-23: 156 pg/mL (elevated)
IL-17A: 89 pg/mL (elevated)
TNF-α: 12 pg/mL (normal)
Calprotectin: 482 µg/g (high inflammation)

Recommended Biologics:

  • 1 Skyrizi (risankizumab) - 96% match - IL-23 inhibitor
  • 2 Stelara (ustekinumab) - 94% match - IL-12/23 inhibitor
  • 3 Humira (adalimumab) - 62% match - TNF-α inhibitor (not optimal for Sarah)

Outcome: Sarah started Skyrizi and achieved clinical remission within 12 weeks. She avoided 18+ months of trial-and-error with TNF-α inhibitors that wouldn't have worked for her IL-23-dominant pathways.

Ready to Find Your Right Treatment?

Stop guessing. Get your CrohnProfile and start with the biologic designed for YOUR immune system.

Order Your Panel →